NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

There is an urgent need to identify vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). PDAC cells acquire metabolic changes that augment NADPH production and cytosolic redox homeostasis. Here, we show that high NADPH levels drive activity of NADPH oxidase 4 (NOX4) expressed in the endoplasmic reticulum (ER) membrane. NOX4 produces H2O2 metabolized by peroxiredoxin 4 (PRDX4) …

Continue reading NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

The #COVID-19 #anxiety syndrome scale: Development and psychometric properties

The central aim of our study was to widen the mental health response to the COVID-19 pandemic by developing and evaluating a measure that could be used to identify the presence of anxiety syndrome features associated with COVID-19. In Study 1, a community sample of 292 participants completed the newly developed COVID-19 Anxiety Syndrome Scale …

Continue reading The #COVID-19 #anxiety syndrome scale: Development and psychometric properties