Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following FMT for rCDI. MethodsSera from two prospective multicentre randomized controlled trials were analyzed for miRNA levels using the Nanostring nCounter platform and quantitative …

Continue reading Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

Western-style #diet impedes colonization and clearance of #Citrobacter rodentium

Western-style diet (WSD), which is high in fat and low in fiber, lacks nutrients to support gut microbiota. Consequently, WSD reduces microbiota density and promotes microbiota encroachment, potentially influencing colonization resistance, immune system readiness, and thus host defense against pathogenic bacteria. Here we examined the impact of WSD on infection and colitis in response to …

Continue reading Western-style #diet impedes colonization and clearance of #Citrobacter rodentium