Systems level profiling of #chemotherapy-induced stress resolution in #cancer cells reveals druggable trade-offs

Cancer therapies often fail to cure patients because a proportion of tumor cells withstand the toxic effects of chemotherapy. How surviving cancer cells recover from sublethal drug-induced stress is not known, but given that cellular resources are finite, stress resolution may come at the expense of less essential systems. Here, we studied the global cellular events of stress buildup and resolution in the bone marrow … Continue reading Systems level profiling of #chemotherapy-induced stress resolution in #cancer cells reveals druggable trade-offs

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#Disruption of the blood−brain barrier in 22q11.2 deletion syndrome

Neuroimmune dysregulation is implicated in neuropsychiatric disorders including schizophrenia. As the blood−brain barrier is the immunological interface between the brain and the periphery, we investigated whether this vascular phenotype is intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome (22qDS). Blood−brain barrier like endothelium differentiated from human 22qDS+schizophrenia-induced pluripotent stem cells exhibited impaired barrier integrity, a phenotype substantiated in … Continue reading #Disruption of the blood−brain barrier in 22q11.2 deletion syndrome

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