Non-steroidal anti-inflammatory drug use and outcomes of #COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

Early in the pandemic it was suggested that pre-existing use of non-steroidal anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with COVID-19. NSAIDs are an important analgesic, particularly in those with rheumatological disease, and are widely available to the general public without prescription. Evidence from community studies, administrative data, and small studies of hospitalised patients suggest NSAIDs are not associated with poorer … Continue reading Non-steroidal anti-inflammatory drug use and outcomes of #COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

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#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age

To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD), we analyzed cross-sectional data from the German Longitudinal Cognitive Impairment and Dementia Study Method: The sample (n=512, mean age: 69.5±5.9 years) included 169 cognitively normal participants and subjects at higher AD risk (53 AD relatives, 209 SCD and 81 MCI). We defined MeDi adherence based … Continue reading #Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age

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Task-Dependent Functional and Effective #Connectivity during Conceptual Processing

Conceptual knowledge is central to cognition. Previous neuroimaging research indicates that conceptual processing involves both modality-specific perceptual-motor areas and multimodal convergence zones. For example, our previous functional magnetic resonance imaging (fMRI) study revealed that both modality-specific and multimodal regions respond to sound and action features of concepts in a task-dependent fashion (Kuhnke P, Kiefer M, Hartwigsen G. 2020b. Task-dependent recruitment of modality-specific and multimodal regions … Continue reading Task-Dependent Functional and Effective #Connectivity during Conceptual Processing

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The oral #microbiome in early #rheumatoid arthritis patients and individuals at risk differs from healthy controls

It has been suggested that rheumatoid arthritis (RA) may originate at the oral mucosa. Our aim was to assess the oral microbiome and the periodontal condition in patients with early rheumatoid arthritis (ERA) and individuals at risk of RA. MethodsThree groups were recruited (50 participants each): (1) ERA patients (2010 ACR/EULAR criteria), (2) at‐risk individuals (arthralgia and autoantibodies), and (3) healthy controls. A periodontal examination … Continue reading The oral #microbiome in early #rheumatoid arthritis patients and individuals at risk differs from healthy controls

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NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

There is an urgent need to identify vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). PDAC cells acquire metabolic changes that augment NADPH production and cytosolic redox homeostasis. Here, we show that high NADPH levels drive activity of NADPH oxidase 4 (NOX4) expressed in the endoplasmic reticulum (ER) membrane. NOX4 produces H2O2 metabolized by peroxiredoxin 4 (PRDX4) in the ER lumen. Using functional genomics and subsequent in … Continue reading NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

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The #COVID-19 #anxiety syndrome scale: Development and psychometric properties

The central aim of our study was to widen the mental health response to the COVID-19 pandemic by developing and evaluating a measure that could be used to identify the presence of anxiety syndrome features associated with COVID-19. In Study 1, a community sample of 292 participants completed the newly developed COVID-19 Anxiety Syndrome Scale (C-19ASS) and results were subjected to a Principal Components Analysis. … Continue reading The #COVID-19 #anxiety syndrome scale: Development and psychometric properties

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#Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women

Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined. Design In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake in adulthood and adolescence with EO-CRC risk among 95 464 women … Continue reading #Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women

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Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study

In 2015, a patient in hospice with Alzheimer’s disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was observed. These improvements were so momentous that she was discharged from the hospice to a long-term care home. Based on this case, we conducted a pilot clinical trial to examine the effect of low-dose ionizing … Continue reading Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study

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Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following FMT for rCDI. MethodsSera from two prospective multicentre randomized controlled trials were analyzed for miRNA levels using the Nanostring nCounter platform and quantitative RT-PCR. Additionally, rCDI-FMT and toxin-treated animals and ex vivo human … Continue reading Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

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Western-style #diet impedes colonization and clearance of #Citrobacter rodentium

Western-style diet (WSD), which is high in fat and low in fiber, lacks nutrients to support gut microbiota. Consequently, WSD reduces microbiota density and promotes microbiota encroachment, potentially influencing colonization resistance, immune system readiness, and thus host defense against pathogenic bacteria. Here we examined the impact of WSD on infection and colitis in response to Citrobacter rodentium. We observed that, relative to mice consuming standard … Continue reading Western-style #diet impedes colonization and clearance of #Citrobacter rodentium

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MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies

The risk of being exposed to Covid-19 indoors can be as great at 60 feet as it is at 6 feet in a room where the air is mixed.Existing safety guidelines have omitted too many factors to accurately quantify the risk of airborne transmission, such as time, mask use and ventilation rates.Bazant and Bush question long-held Covid-19 guidelines that recommend 6 feet of distance between … Continue reading MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies

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#Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort

Cognitive leisure activity, such as reading, playing mahjong or cards and computer use, is common among older adults in China. Previous studies suggest a negative correlation between cognitive leisure activity and cognitive impairment. However, the relationship between cognitive leisure activity and all-cause mortality has rarely been reported. ObjectivesThis study aims to explore the relationships between cognitive leisure activity and all-cause mortality in a community-based older … Continue reading #Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort

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