Causal Effect of #Tooth Loss on Functional Capacity in Older Adults in England: A Natural Experiment

Background/ObjectivesTooth loss is associated with reduced functional capacity, but so far, there is no relevant causal evidence reported. We investigated the causal effect of tooth loss on the instrumental activities of daily living (IADL) among older adults in England. DesignNatural experiment study with instrumental variable analysis. SettingThe English Longitudinal Study of Aging (ELSA) combined with …

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Increased #Risk of Stroke in Patients With #Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study

Patients with obsessive-compulsive disorder (OCD) tend to be comorbid with stroke-related risk factors, including obesity, hypertension, and diabetes. However, the temporal association between OCD and subsequent stroke risk is unclear. Methods:Using data collected between 2001 and 2010 by Taiwan’s National Health Insurance Research Database, 28 064 adult patients with OCD (International Classification of Diseases, Ninth …

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Genetically Proxied Diurnal Preference, #Sleep Timing, and Risk of Major #Depressive Disorder

Morning diurnal preference is associated with reduced risk of major depressive disorder (MDD); however, causality in this association is uncertain. Objective To examine the association of genetically proxied morning diurnal preference with depression risk using mendelian randomization. Design, Setting, and Participants This 2-sample mendelian randomization study used summary-level genetic associations with diurnal preference and MDD. …

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#Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial

Few pharmacological interventions are available for cancer-associated anorexia and cachexia. Mirtazapine has been suggested for use in cancer-associated anorexia and cachexia. ObjectivesThis study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia. MethodsA double-blind placebo-controlled randomized trial. The study included 120 incurable solid tumour patients with anorexia (appetite loss …

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#Thyroid dysfunction and #breast cancer risk among women in the UK Biobank cohort

This study aimed to evaluate the association between thyroid dysfunction and breast cancer risk. We included 239,436 females of the UK Biobank cohort. Information on thyroid dysfunction, personal and family medical history, medications, reproductive factors, lifestyle, and socioeconomic characteristics was retrieved from baseline self-reported data and hospital inpatient databases. Breast cancer diagnoses were identified through …

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