Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women

Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio … Continue reading Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women

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Therapeutic Repurposing of #Biguanides in #Cancer

Biguanides exert antitumor activities through various biochemical mechanisms involving mitochondrial complex I, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and/or mitochondrial glycerophosphate dehydrogenase (mGPD). Biguanides selectively target subpopulations of cancer cells addicted to oxidative phosphorylation (OXPHOS). Metabolic adaptations triggered by biguanide exposure could be potential targets to improve the antitumor efficacy of biguanides. Biguanides modulate antitumor immunity by targeting immune cells in the … Continue reading Therapeutic Repurposing of #Biguanides in #Cancer

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