Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder

Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine on cognitive function in these disorders is not well understood. To address this gap, we examined the effect of a single dose of IV ketamine on cognition in individuals with MDD and/or PTSD relative to healthy controls … Continue reading Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder

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Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults

Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. Research Question Does a single high-dose (540,000 IU) enteral treatment of vitamin D3 given shortly after hospital admission in vitamin D deficient, critically-ill patients improve long-term global cognition or executive function? Study Design and Methods This study evaluated long-term cognitive outcomes among patients enrolled in a multicenter, blinded, randomized … Continue reading Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults

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