#Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan … Continue reading #Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

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#Sotatercept for the Treatment of Pulmonary Arterial #Hypertension

Pulmonary arterial hypertension is characterized by pulmonary vascular remodeling, cellular proliferation, and poor long-term outcomes. Dysfunctional bone morphogenetic protein pathway signaling is associated with both hereditary and idiopathic subtypes. Sotatercept, a novel fusion protein, binds activins and growth differentiation factors in the attempt to restore balance between growth-promoting and growth-inhibiting signaling pathways. METHODS In this 24-week multicenter trial, we randomly assigned 106 adults who were … Continue reading #Sotatercept for the Treatment of Pulmonary Arterial #Hypertension

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