#Smoking, #Radiation Therapy, and Contralateral #Breast Cancer Risk in Young Women

Evidence is mounting that cigarette smoking contributes to second primary contralateral breast cancer (CBC) risk. Whether radiation therapy (RT) interacts with smoking to modify this risk is unknown. In this multicenter, individually-matched case-control study, we examined the association between RT, smoking, and CBC risk. The study included 1,521 CBC cases and 2,212 controls with unilateral breast cancer, all diagnosed with first invasive breast cancer between … Continue reading #Smoking, #Radiation Therapy, and Contralateral #Breast Cancer Risk in Young Women

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Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study

Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe APAP‐related ALI in our center were included from 2002 to … Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study

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