A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent #glioblastoma

Glioblastoma (GBM) is one of the most difficult cancers to effectively treat, in part because of the lack of precision therapies and limited therapeutic access to intracranial tumor sites due to the presence of the blood-brain and blood-tumor barriers. We have developed a precision medicine approach for GBM treatment that involves the use of brain-penetrant RNA interference–based spherical nucleic acids (SNAs), which consist of gold … Continue reading A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent #glioblastoma

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Do #β-Blockers Cause #Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy

β-Blockers are important drugs in the treatment of cardiovascular diseases. They are suspected of inducing various psychiatric adverse events (PAEs), particularly depression, affecting cardiovascular morbidity and mortality. We performed a systematic search for double-blind, randomized controlled trials investigating β-blockers to analyze the risk of PAEs or withdrawal of therapy due to PAEs. We extracted the frequencies of PAEs and rates of withdrawals and reviewed them … Continue reading Do #β-Blockers Cause #Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy

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