Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (ECM)–mimicking hydrogel using catalyst-free click chemistry covalent bonding between two elastin-like recombinamers (ELRs). The resulting customized hydrogel included functional domains for cell adhesion and protease cleavage sites, sensitive to cleavage by matrix metalloproteases overexpressed after myocardial infarction (MI). The … Continue reading Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

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Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor uptake of the progestin analog, 21-[18F]fluorofuranylnorprogesterone (FFNP), before and after … Continue reading Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

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