#Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic implications for immune cells, such as monocytes and macrophages, exposed to elevated levels of dietary fructose is limited. Here, we show that fructose reprograms cellular metabolic pathways to favour glutaminolysis and oxidative metabolism, which are … Continue reading #Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

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Clinical and Biological Correlates of White Matter Hyperintensities in Patients with #Behavioral-variant Frontotemporal #Dementia and #Alzheimer Disease

To test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses. Methods: 129 patients (64 bvFTD, 65 AD) and 66 controls underwent high-resolution brain MRI, clinical and neuropsychological examination. Genetic screening was conducted … Continue reading Clinical and Biological Correlates of White Matter Hyperintensities in Patients with #Behavioral-variant Frontotemporal #Dementia and #Alzheimer Disease

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Risk‐adapted starting age of #breast cancer screening in women with a family history of #ovarian or other cancers: A nationwide cohort study

There is a lack of evidence‐based recommendations for the age at which women with a family history of cancers other than breast cancer should start breast cancer screening. METHODS Using Swedish family cancer data sets, the authors conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931 (follow‐up, 1958‐2015). Accounting for calendar time, they calculated the relative risk of breast cancer for women … Continue reading Risk‐adapted starting age of #breast cancer screening in women with a family history of #ovarian or other cancers: A nationwide cohort study

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#Personality pathways to mortality: Interleukin-6 links conscientiousness to #mortality risk

Personality is associated consistently with mortality hazards, but the physiological pathways are not yet clear. Immune system dysregulation may be one such pathway due to its role in age-related morbidity and mortality. In this preregistered study, we tested whether interleukin-6 (IL-6) and C-reactive protein (CRP) mediated the associations between personality traits and mortality hazards. The sample included 957 participants (M ± SD = 58.65 ± … Continue reading #Personality pathways to mortality: Interleukin-6 links conscientiousness to #mortality risk

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#Statin treatment and #muscle symptoms: series of randomised, placebo controlled n-of-1 trials

To establish the effect of statins on muscle symptoms in people who had previously reported muscle symptoms when taking statins. Design Series of randomised, placebo controlled n-of-1 trials. Setting Primary care across 50 sites in the United Kingdom, December 2016 to April 2018. Participants 200 participants who had recently stopped or were considering stopping treatment with statins because of muscle symptoms. Interventions Participants were randomised … Continue reading #Statin treatment and #muscle symptoms: series of randomised, placebo controlled n-of-1 trials

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Analysis of Active and Passive #Tobacco Exposures and Blood #Pressure in US Children and Adolescents

..Elevated blood pressure, classified as greater than 90% for a child’s age, sex, and height according to the 2017 American Academy of Pediatrics Clinical Practice Guidelines. The a priori hypothesis that there is a positive association between tobacco exposure and elevated blood pressure in the study population was tested. Analysis included logistic regression with adjustment for possible confounders. Subgroup and sensitivity analyses were conducted. Results … Continue reading Analysis of Active and Passive #Tobacco Exposures and Blood #Pressure in US Children and Adolescents

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Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation

Adherent-invasive E. coli (AIEC) are enriched in the intestinal microbiota of patients with Crohn’s disease (CD) and promote intestinal inflammation. Yet, how AIEC metabolism of nutrients impacts intestinal homeostasis is poorly defined. Here, we show that AIEC encoding the large subunit of propanediol dehydratase (PduC), which facilitates the utilization of fucose fermentation product 1,2-propanediol, are increased in the microbiome of CD patients and drive AIEC-induced … Continue reading Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation

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Early initiation of prophylactic #anticoagulation for prevention of #coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

To evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States. Design Observational cohort study. Setting Nationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare system. Participants All 4297 patients admitted to hospital from 1 … Continue reading Early initiation of prophylactic #anticoagulation for prevention of #coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

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Effect of Telephone #Cognitive Behavioral Therapy for Insomnia in Older Adults With #Osteoarthritis Pain

Scalable delivery models of cognitive behavioral therapy for insomnia (CBT-I), an effective treatment, are needed for widespread implementation, particularly in rural and underserved populations lacking ready access to insomnia treatment. Objective To evaluate the effectiveness of telephone CBT-I vs education-only control (EOC) in older adults with moderate to severe osteoarthritis pain. Design, Setting, and Participants This is a randomized clinical trial of 327 participants 60 … Continue reading Effect of Telephone #Cognitive Behavioral Therapy for Insomnia in Older Adults With #Osteoarthritis Pain

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Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (ECM)–mimicking hydrogel using catalyst-free click chemistry covalent bonding between two elastin-like recombinamers (ELRs). The resulting customized hydrogel included functional domains for cell adhesion and protease cleavage sites, sensitive to cleavage by matrix metalloproteases overexpressed after myocardial infarction (MI). The … Continue reading Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

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Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor uptake of the progestin analog, 21-[18F]fluorofuranylnorprogesterone (FFNP), before and after … Continue reading Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

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#Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease

While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer’s disease (AD). Material and methods We analysed data on 2394 apparently healthy men with good baseline … Continue reading #Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease

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