Distinct developmental pathways from blood #monocytes generate human #lung macrophage diversity

The study of human macrophages and their ontogeny is an important unresolved issue. Here, we use a humanized mouse model expressing human cytokines to dissect the development of lung macrophages from human hematopoiesis in vivo. Human CD34+ hematopoietic stem and progenitor cells (HSPCs) generated three macrophage populations, occupying separate anatomical niches in the lung. Intravascular cell labeling, cell transplantation, and fate-mapping studies established that classical … Continue reading Distinct developmental pathways from blood #monocytes generate human #lung macrophage diversity

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U.S. #Diet Guidelines Sidestep Scientific Advice to Cut #Sugar and #Alcohol

..Evidence suggests that added sugars, particularly those in sweetened beverages, may contribute to obesity and weight gain, which are linked to higher rates of chronic health conditions like heart disease and Type 2 diabetes, the scientific panel noted. More than two-thirds of American adults are overweight or obese; obesity, diabetes and other related conditions also increase the risk of developing severe Covid-19 illness. The scientific … Continue reading U.S. #Diet Guidelines Sidestep Scientific Advice to Cut #Sugar and #Alcohol

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