#Endoscopy-related #bleeding and thromboembolic events in patients on direct oral anticoagulants or vitamin K antagonists

Few prospective studies have assessed the safety of direct oral anticoagulants (DOACs) in elective endoscopy. Our primary aim was to compare the risks of endoscopy-related gastrointestinal bleeding and thromboembolic events in patients on DOACs or vitamin K antagonists (VKAs) in this setting. Secondarily, we examined the impact of the timing of anticoagulant resumption on the risk of delayed bleeding in high-risk therapeutic procedures.. The 2 … Continue reading #Endoscopy-related #bleeding and thromboembolic events in patients on direct oral anticoagulants or vitamin K antagonists

Rate This

BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury

Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to only a subset of injuries with substantially breached BBB. We report … Continue reading BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury

Rate This