Elevated ectodomain of type 23 #collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in #ulcerative colitis and #Crohnโ€™s disease

Impaired intestinal epithelial barrier is highly affected in inflammatory bowel disease. Transmembrane collagens connecting the epithelial cells to the extracellular matrix have an important role in epithelial cell homeostasis. Thus, we sought to determine whether the transmembrane type 23 collagen could serve as a surrogate marker for disease activity in patients with Crohnโ€™s disease and ulcerative colitis.. In the acute and chronic dextran sulfate sodium-induced … Continue reading Elevated ectodomain of type 23 #collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in #ulcerative colitis and #Crohnโ€™s disease

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#Biomarkers, disability and health care demand

Using longitudinal data from a representative UK panel, we focus on a group of apparently healthy individuals with no history of disability or major chronic health condition at baseline. A latent variable structural equation model is used to analyse the predictive role of latent baseline biological health, indicated by a rich set of biomarkers, and other personal characteristics, in determining the individualโ€™s disability state and … Continue reading #Biomarkers, disability and health care demand

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