PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against #gestational #diabetes in mice and humans

Pregnancy is a physiological state of continuous adaptation to changing maternal and fetal nutritional needs, including a reduction of maternal insulin sensitivity allowing for appropriately enhanced glucose availability to the fetus. However, excessive insulin resistance in conjunction with insufficient insulin secretion results in gestational diabetes mellitus (GDM), greatly increasing the risk for pregnancy complications and predisposing both mothers and offspring to future metabolic disease. Here, … Continue reading PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against #gestational #diabetes in mice and humans

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Gut #microbiota depletion by chronic antibiotic treatment alters the #sleep/wake architecture and sleep #EEG power spectra in mice

Dysbiosis of the gut microbiota affects physiological processes, including brain functions, by altering the intestinal metabolism. Here we examined the effects of the gut microbiota on sleep/wake regulation. C57BL/6 male mice were treated with broad-spectrum antibiotics for 4 weeks to deplete their gut microbiota. Metabolome profiling of cecal contents in antibiotic-induced microbiota-depleted (AIMD) and control mice showed significant variations in the metabolism of amino acids … Continue reading Gut #microbiota depletion by chronic antibiotic treatment alters the #sleep/wake architecture and sleep #EEG power spectra in mice

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