#Levothyroxine dose and risk of atrial #fibrillation: A nested case-control study

On Nov 30, 2020 By aledopressIn Cardiology, Endocrinology

Contemporary data on the effect of levothyroxine dose on the occurrence of atrial fibrillation (AF) are lacking, particularly in the older population. Our objective was to determine the effect of cumulative levothyroxine exposure on risk of AF and ischemic stroke in older adults We conducted a population-based observational study using health care databases from Ontario, …

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#Aprotinin Inhibits #SARS-CoV-2 Replication

On Nov 30, 2020 By aledopressIn Infectivology

Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S) protein by cellular proteases. Herein, we showed that the protease inhibitor aprotinin (but not the protease inhibitor SERPINA1/alpha-1 antitrypsin) …

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