#Levothyroxine dose and risk of atrial #fibrillation: A nested case-control study

Contemporary data on the effect of levothyroxine dose on the occurrence of atrial fibrillation (AF) are lacking, particularly in the older population. Our objective was to determine the effect of cumulative levothyroxine exposure on risk of AF and ischemic stroke in older adults We conducted a population-based observational study using health care databases from Ontario, Canada. We identified adults aged ≥66 years without a history … Continue reading #Levothyroxine dose and risk of atrial #fibrillation: A nested case-control study

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#Aprotinin Inhibits #SARS-CoV-2 Replication

Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S) protein by cellular proteases. Herein, we showed that the protease inhibitor aprotinin (but not the protease inhibitor SERPINA1/alpha-1 antitrypsin) inhibited SARS-CoV-2 replication in therapeutically achievable concentrations. An analysis of … Continue reading #Aprotinin Inhibits #SARS-CoV-2 Replication

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