The gut #microbiota is associated with #immune cell dynamics in humans

The gut microbiota influences development and homeostasis of the mammalian immune system, and is associated with human inflammatory and immune diseases as well as responses to immunotherapy. Nevertheless, our understanding of how gut bacteria modulate the immune system remains limited, particularly in humans, where the difficulty of direct experimentation makes inference challenging. Here we study hundreds of hospitalized—and closely monitored—patients with cancer receiving haematopoietic cell … Continue reading The gut #microbiota is associated with #immune cell dynamics in humans

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Distinct #inflammatory profiles distinguish #COVID-19 from #influenza with limited contributions from #cytokine storm

We pursued a study of immune responses in COVID-19 and influenza cohorts. Compared to influenza patients, COVID-19 patients exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface HLA-class II expression on select monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes was a significant predictor of COVID-19 disease severity. In contrast to prevailing assumptions about COVID-19 disease immunopathology, very few (7 of 168) COVID-19 patients … Continue reading Distinct #inflammatory profiles distinguish #COVID-19 from #influenza with limited contributions from #cytokine storm

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