Partial and Total #Sleep Deprivation Interferes with Neural Correlates of Consolidation of #Fear Extinction #Memory

We assessed the impact of total and partial sleep loss on neural correlates of fear conditioning and extinction learning and recall in healthy young adults. Methods Participants (56.3% female, age 24.8±3.4) were randomized to a night of normal sleep (NS, n=48), sleep restriction (SR, n=53), or sleep deprivation (SD, n=53). All completed fear conditioning and extinction learning phases the following morning. Extinction recall was tested … Continue reading Partial and Total #Sleep Deprivation Interferes with Neural Correlates of Consolidation of #Fear Extinction #Memory

Evaluation of Time to Benefit of #Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years A Meta-analysis

Guidelines recommend targeting preventive interventions toward older adults whose life expectancy is greater than the intervention’s time to benefit (TTB). The TTB for statin therapy is unknown To conduct a survival meta-analysis of randomized clinical trials of statins to determine the TTB for prevention of a first major adverse cardiovascular event (MACE) in adults aged 50 to 75 years.. Eight trials randomizing 65 383 adults (66.3% … Continue reading Evaluation of Time to Benefit of #Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years A Meta-analysis