An Immunomodulatory Therapeutic #Vaccine Targeting Oligomeric #Amyloid-β

Background:Aging is considered the most important risk factor for Alzheimer’s disease (AD). Recent research supports the theory that immunotherapy targeting the “oligomeric” forms of amyloid-β (Aβ) may halt the progression of AD. However, previous clinical trial of the vaccine against Aβ, called AN1792, was suspended due to cases of meningoencephalitis in patients. Objective:To develop a peptide sensitized dendritic cells (DCs) vaccine that would target oligomer … Continue reading An Immunomodulatory Therapeutic #Vaccine Targeting Oligomeric #Amyloid-β

#SARS-CoV-2 seroprevalence and #transmission risk factors among high-risk close contacts: a retrospective cohort study

The proportion of asymptomatic carriers and transmission risk factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among household and non-household contacts remains unclear. In Singapore, extensive contact tracing by the Ministry of Health for every diagnosed COVID-19 case, and legally enforced quarantine and intensive health surveillance of close contacts provided a rare opportunity to determine asymptomatic attack rates and SARS-CoV-2 transmission risk factors among … Continue reading #SARS-CoV-2 seroprevalence and #transmission risk factors among high-risk close contacts: a retrospective cohort study