#SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2’s Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) – a pro-nociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. VEGF-A–triggered sensory neuronal firing … Continue reading #SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

Association Between Time to Colonoscopy after Positive Fecal Testing and Colorectal Cancer Outcomes: a Systematic Review

Colonoscopy is required following a positive fecal screening test for colorectal cancer (CRC). It remains unclear to what extent time to colonoscopy is associated with CRC-related outcomes. We performed a systematic review to elucidate this relationship.. ..From 1,612 initial studies, 8 were included in the systematic review, with 5 reporting outcomes for FIT. Although meta-analysis was not possible, consistent trends between longer time delays and … Continue reading Association Between Time to Colonoscopy after Positive Fecal Testing and Colorectal Cancer Outcomes: a Systematic Review