Transcriptomic and clonal characterization of #T cells in the human central #nervous system

T cells provide critical immune surveillance to the central nervous system (CNS), and the cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further characterization of the state of T cells in the CSF in healthy individuals is important for understanding how T cells provide protective immune surveillance without damaging the delicate environment of the CNS and providing tissue-specific context for … Continue reading Transcriptomic and clonal characterization of #T cells in the human central #nervous system

Randomized Trial of Nocturnal #Oxygen in Chronic #Obstructive Pulmonary Disease

Long-term oxygen therapy improves survival in patients with chronic obstructive pulmonary disease (COPD) and chronic severe daytime hypoxemia. However, the efficacy of oxygen therapy for the management of isolated nocturnal hypoxemia is uncertain.. ..Patients with an oxygen saturation of less than 90% for at least 30% of the recording time on nocturnal oximetry were assigned, in a 1:1 ratio, to receive either nocturnal oxygen or … Continue reading Randomized Trial of Nocturnal #Oxygen in Chronic #Obstructive Pulmonary Disease