An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study

..We found evidence of causal associations between 34 exposures (19 risk factors and 15 protective factors) and type 2 diabetes. Insomnia was identified as a novel risk factor (OR 1.17 [95% CI 1.11, 1.23]). The other 18 risk factors were depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine and leucine, liver alanine aminotransferase, childhood and adulthood BMI, body fat percentage, … Continue reading An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study

Effects of Intensive Blood Pressure Treatment on Orthostatic #Hypotension

Although intensive blood pressure (BP)–lowering treatment reduces risk for cardiovascular disease, there are concerns that it might cause orthostatic hypotension (OH).. ..Randomized trials of BP pharmacologic treatment (more intensive BP goal or active agent) that involved more than 500 adults with hypertension or elevated BP and that were 6 months or longer in duration. Trial comparisons were groups assigned to either less intensive BP goals … Continue reading Effects of Intensive Blood Pressure Treatment on Orthostatic #Hypotension