#Placebos without deception reduce self-report and neural measures of emotional #distress

Several recent studies suggest that placebos administered without deception (i.e., non-deceptive placebos) can help people manage a variety of highly distressing clinical disorders and nonclinical impairments. However, whether non-deceptive placebos represent genuine psychobiological effects is unknown. Here we address this issue by demonstrating across two experiments that during a highly arousing negative picture viewing task, non-deceptive placebos reduce both a self-report and neural measure of … Continue reading #Placebos without deception reduce self-report and neural measures of emotional #distress

Heterogeneity and clonal relationships of adaptive immune cells in #ulcerative colitis revealed by single-cell analyses

Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders driven by dysregulated immune responses against gut microbiota. We integrated single-cell RNA and antigen receptor sequencing to elucidate key components, cellular states, and clonal relationships of the peripheral and gastrointestinal mucosal immune systems in health and ulcerative colitis (UC). UC was associated with an increase in IgG1+ plasma cells in colonic tissue, increased colonic regulatory … Continue reading Heterogeneity and clonal relationships of adaptive immune cells in #ulcerative colitis revealed by single-cell analyses