Efficacy and safety of gastrointestinal #bleeding prophylaxis in critically #ill patients: an updated systematic review and network meta-analysis of randomized trials

Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastrointestinal bleeding prophylaxis in critically ill patients. Seventy-four trials enrolling 39 569 patients proved eligible. Both PPIs (risk ratio (RR) 1.03, … Continue reading Efficacy and safety of gastrointestinal #bleeding prophylaxis in critically #ill patients: an updated systematic review and network meta-analysis of randomized trials