The ubiquitous flavonoid #quercetin is an atypical KCNQ #potassium channel activator

Many commonly consumed plants are used as folk medicines, often with unclear molecular mechanisms. Recent studies uncovered the ubiquitous and influential KCNQ family of voltage-gated potassium (Kv) channels as a therapeutic target for several medicinal plant compounds. Capers – immature flower buds of Capparis spinosa – have been consumed for food and medicinal purposes for millennia. Here, we show that caper extract hyperpolarizes cells expressing … Continue reading The ubiquitous flavonoid #quercetin is an atypical KCNQ #potassium channel activator

Risk factors of excessive daytime #sleepiness in a prospective population‐based cohort

Although excessive daytime sleepiness is commonly evaluated in clinical and research settings using the Epworth Sleepiness Scale, few studies have assessed the factors associated with its incidence in the general population. We prospectively investigated the predictors of incident and persistent excessive daytime sleepiness in 2,751 subjects (46.1% men, mean age 56.0 ± 9.8 years) from the CoLaus‐PsyCoLaus population‐based cohort (Lausanne, Switzerland) over 5 years. Participants … Continue reading Risk factors of excessive daytime #sleepiness in a prospective population‐based cohort