Generative Feedback Explains Distinct Brain Activity Codes for Seen and Mental Images

The relationship between mental imagery and vision is a long-standing problem in neuroscience. Currently, it is not known whether differences between the activity evoked during vision and reinstated during imagery reflect different codes for seen and mental images. To address this problem, we modeled mental imagery in the human brain as feedback in a hierarchical generative network. Such networks synthesize images by feeding abstract representations … Continue reading Generative Feedback Explains Distinct Brain Activity Codes for Seen and Mental Images

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

Dietary lipids impact development, homeostasis, and disease, but links between specific dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of nonapoptotic cell death associated with oxidized polyunsaturated phospholipids. Here, we show that dietary ingestion of the polyunsaturated fatty acid (PUFA) dihomogamma-linolenic acid (DGLA; 20:3n-6) can trigger germ-cell ferroptosis and sterility in the nematode Caenorhabditis elegans. Exogenous DGLA is also sufficient … Continue reading Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells