Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro

Potential drug treatments for Alzheimer’s disease (AD) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. Here, a small library of structurally diverse compounds was screened in vitro for the ability to inhibit tau aggregation, using high-throughput synchrotron radiation circular dichroism as a novel tool to monitor the structural … Continue reading Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro

Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults

The potential of physical activity (PA) to attenuate the effects of alcohol consumption on the risks of alcohol‐related cancer mortality is unknown. We used data from participants aged 30 years and over in 10 British population‐based surveys (Health Surveys for England 1994, 1997, 1998, 1999, 2003, 2004, 2006 and 2008 and the Scottish Health Surveys 1998 and 2003). Alcohol‐related cancer mortality included oral cavity, throat, larynx, … Continue reading Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults