Environmental Factors and Host Microbiomes Shape Host–Pathogen Dynamics

In many cases, interactions among host, pathogen, and environment are insufficient to describe disease dynamics in the wild. The host microbiome plays an important role in host immunity, at the interface between the host and the pathogen, and affects disease outcome. The environment, as well as environmental microbiomes, influence the host microbiome, and also influence simultaneously the host and the pathogen. The three-edged disease triangle … Continue reading Environmental Factors and Host Microbiomes Shape Host–Pathogen Dynamics

Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis

Malnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essential for many cellular processes including antioxidant pathways. The prevalence and relevance of trace element deficiency is unknown in alcoholic hepatitis. ..Sera from 302 patients with alcoholic hepatitis, 46 with alcohol‐related cirrhosis and 15 healthy controls … Continue reading Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis