ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19

Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes, and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV2 to bind and enter host cells, no study has systematically assessed the ACE2 expression in the lungs of patients with these diseases. Here, we analyzed over 700 lung transcriptome samples of patients with comorbidities associated with severe COVID-19 and … Continue reading ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19

Current and 1-Year Psychological and Physical Effects of Replacing Sedentary Time With Time in Other Behaviors

Sedentary time is inversely associated with health. Capturing 24 hours of behavior (i.e., sleep, sedentary, light physical activity, and moderate-to-vigorous physical activity) is necessary to understand behavior–health associations.. ..Cross-sectional analyses revealed substituting prolonged sedentary time for sleep was associated with lower stress (standardized β= −0.11), better mood (−0.12), and lower BMI (−0.10). Substituting total or prolonged sedentary for moderate-to-vigorous physical activity was associated with lower … Continue reading Current and 1-Year Psychological and Physical Effects of Replacing Sedentary Time With Time in Other Behaviors