Potential pathophysiology of heart failure with preserved ejection fraction (HFpEF) has not been fully explored. The aim of the study was to reveal the association of serum calcium concentration at baseline with 12‐month clinical outcome in the disease..
..Multivariate COX regression analysis revealed that baseline hypocalcaemia was associated with the increased risk of cardiac re‐hospitalization and death during the follow‐up period (HR: 2.10, 95% CI: 1.69‐2.61; HR: 8.26, 95% CI: 2.88‐23.70). Furthermore, baseline hypocalcaemia was related to the deterioration of 6‐minute walk distance, quality of life score (EQ‐5D), right quadriceps strength, left atrium volume index and left ventricular ejection fraction during the follow‐up period (HR: 1.65, 95% CI: 1.21‐2.26; HR: 1.55, 95% CI: 1.12‐2.11; HR: 2.56, 95% CI: 1.68‐3.89; HR: 1.44, 95% CI: 1.03‐1.98; HR: 1.36, 95% CI: 1.02‐1.80).
Baseline hypocalcaemia predicted 12‐month cardiac re‐hospitalization and death in HFpEF patients without calcium and vitamin D supplements partly through left ventricle and skeletal muscle function pathways.