Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models

..Stable treatment response, intended as a proxy for treatment effectiveness, defined as continued prescription of an antidepressant for 90 days. Supervised topic models were used to extract 10 interpretable covariates from coded clinical data for stability prediction. With use of data from 1 hospital system (site A), generalized linear models and ensembles of decision trees were trained to predict stability outcomes from topic features that … Continue reading Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models

#Hypocalcaemia predicts 12‐month re‐hospitalization in heart #failure

Potential pathophysiology of heart failure with preserved ejection fraction (HFpEF) has not been fully explored. The aim of the study was to reveal the association of serum calcium concentration at baseline with 12‐month clinical outcome in the disease.. ..Multivariate COX regression analysis revealed that baseline hypocalcaemia was associated with the increased risk of cardiac re‐hospitalization and death during the follow‐up period (HR: 2.10, 95% CI: … Continue reading #Hypocalcaemia predicts 12‐month re‐hospitalization in heart #failure