Oral #fluconazole use in the first trimester and risk of congenital #malformations: population based cohort study

..The study cohort of 1 969 954 pregnancies included 37 650 (1.9%) pregnancies exposed to oral fluconazole and 82 090 (4.2%) pregnancies exposed to topical azoles during the first trimester. The risk of musculoskeletal malformations was 52.1 (95% confidence interval 44.8 to 59.3) per 10 000 pregnancies exposed to fluconazole versus 37.3 (33.1 to 41.4) per 10 000 pregnancies exposed to topical azoles. The risks of conotruncal malformations were 9.6 (6.4 … Continue reading Oral #fluconazole use in the first trimester and risk of congenital #malformations: population based cohort study

Assessment of #dextrose 50 bolus versus dextrose 10 infusion in the management of #hyperkalemia in the ED

Hypoglycemia is a common adverse effect when intravenous (IV) insulin is administered for hyperkalemia. A prolonged infusion of dextrose 10% (D10) may mitigate hypoglycemia compared to dextrose 50% (D50) bolus. Our objective was to evaluate whether D10 infusion is a safe and effective alternative to D50 bolus for hypoglycemia prevention in hyperkalemic patients receiving IV insulin.. ..There was no difference in incidence of hypoglycemia between … Continue reading Assessment of #dextrose 50 bolus versus dextrose 10 infusion in the management of #hyperkalemia in the ED