Emotional #Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5–CPEB3–GluA1 Pathway

..SIGNIFICANCE STATEMENT Astrocytes play important roles in synaptic transmission by extending fine processes around synapses. In this study, we showed that a single exposure to an acute stress triggered a retraction of lateral/fine processes in mouse cerebellar astrocytes. These astrocytes express GluA1, a glutamate receptor subunit known to lengthen astrocyte processes. We showed that astrocytic structural changes are associated with a reduction of GluA1 protein … Continue reading Emotional #Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5–CPEB3–GluA1 Pathway

#Mood Homeostasis, Low Mood, and History of #Depression in 2 Large Population Samples

..To assess whether mood homeostasis (ie, the stabilization of one’s mood by engaging in mood-modifying activities) is a possible new therapeutic target by testing the hypothesis that people with low (vs high) mean mood and people with (vs without) a history of depression have impaired mood homeostasis.. ..A total of 28 212 participants from the 58sec data set (65.8% female; mean [SD] age, 28.1 [9.0] years) … Continue reading #Mood Homeostasis, Low Mood, and History of #Depression in 2 Large Population Samples