FDA Approves Only Drug in U.S. to Treat Severe #Malaria

Today, the U.S. Food and Drug Administration approved artesunate for injection to treat severe malaria in adult and pediatric patients. Treatment of severe malaria with intravenous (IV) artesunate should always be followed by a complete treatment course of an appropriate oral antimalarial regimen. Prior to this approval, IV artesunate was only available to patients through the FDA’s Expanded Access program, which allowed the U.S. Centers … Continue reading FDA Approves Only Drug in U.S. to Treat Severe #Malaria

Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract

Abstract The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data, we demonstrate that ACE2 is expressed in a subset of secretory cells in the respiratory tract. Chronic smoke exposure triggers the expansion of this cell population and … Continue reading Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract

Predictors of a long length of stay in the emergency department for older people

..For older people, a long stay in the emergency department (ED) may reflect the complexity of their presentation, or deficiencies in systems that manage these complexities. ..Of 16 791 ED presentations made by older people, 4192 experienced a LLoS; 55% were admitted. Increasing age was associated with an increasing ED LoS. Factors most predictive of LLoS for both admitted and discharged patients included: investigations (both pathology … Continue reading Predictors of a long length of stay in the emergency department for older people

#Hydroxychloroquine or #chloroquine with or without a macrolide for treatment of #COVID-19: a multinational registry analysis

Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19.. ..96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during … Continue reading #Hydroxychloroquine or #chloroquine with or without a macrolide for treatment of #COVID-19: a multinational registry analysis

Reducing #antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper

Highlights •Global & national AMR actions focus on infection prevention in healthcare settings. •Home & everyday life settings contribute to acquiring & spreading AMR pathogens. •Targeted hygiene protects against infections, reducing antibiotic prescribing. • Targeted hygiene helps to minimize selection pressure for AMR development globally. •Reducing AMR requires greater focus on targeted hygiene in the home & community. Antimicrobial resistance (AMR) continues to threaten global … Continue reading Reducing #antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper

#Remdesivir for the Treatment of #Covid-19 — Preliminary Report

..We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by … Continue reading #Remdesivir for the Treatment of #Covid-19 — Preliminary Report

Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models

..Stable treatment response, intended as a proxy for treatment effectiveness, defined as continued prescription of an antidepressant for 90 days. Supervised topic models were used to extract 10 interpretable covariates from coded clinical data for stability prediction. With use of data from 1 hospital system (site A), generalized linear models and ensembles of decision trees were trained to predict stability outcomes from topic features that … Continue reading Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models

#Hypocalcaemia predicts 12‐month re‐hospitalization in heart #failure

Potential pathophysiology of heart failure with preserved ejection fraction (HFpEF) has not been fully explored. The aim of the study was to reveal the association of serum calcium concentration at baseline with 12‐month clinical outcome in the disease.. ..Multivariate COX regression analysis revealed that baseline hypocalcaemia was associated with the increased risk of cardiac re‐hospitalization and death during the follow‐up period (HR: 2.10, 95% CI: … Continue reading #Hypocalcaemia predicts 12‐month re‐hospitalization in heart #failure

Physical presence of spouse enhances brain-to-brain synchrony in co-parenting couples

Co-parenting spouses who live together remain in close physical proximity to each other and regularly engage in reciprocal social interactions in joint endeavors to coordinate their caregiving. Although bi-parental rearing is a common occurrence in humans, the influence of the physical presence of a co-parenting spouse on parental brain responses remains largely unknown. Synchrony is conceptualized as the matching of behavioral and physiological signals between … Continue reading Physical presence of spouse enhances brain-to-brain synchrony in co-parenting couples

Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study

COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear.. ..Between 11 and 29 March 2020, 79 patients with IBD with COVID-19 were enrolled at 24 IBD referral units. Thirty-six patients had COVID-19-related pneumonia … Continue reading Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study

Effects of #yoga on depressive symptoms in people with mental disorders: a systematic review and meta-analysis

..Eligibility criteria for selecting studies We included randomised controlled trials with a yoga intervention comprising ≥50% physical activity in adults with a recognised diagnosed mental disorder according to DSM-3, 4 or 5. Results 19 studies were included in the review (1080 participants) and 13 studies were included in the meta-analysis (632 participants). Disorders of depression, post-traumatic stress, schizophrenia, anxiety, alcohol dependence and bipolar were included. … Continue reading Effects of #yoga on depressive symptoms in people with mental disorders: a systematic review and meta-analysis

Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study

There are few primary care studies of the COVID-19 pandemic. We aimed to identify demographic and clinical risk factors for testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre primary care network.. ..We identified 3802 SARS-CoV-2 test results, of which 587 were positive. In multivariable analysis, male sex was independently associated … Continue reading Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study