FDA Approves Only Drug in U.S. to Treat Severe #Malaria

Today, the U.S. Food and Drug Administration approved artesunate for injection to treat severe malaria in adult and pediatric patients. Treatment of severe malaria with intravenous (IV) artesunate should always be followed by a complete treatment course of an appropriate oral antimalarial regimen. Prior to this approval, IV artesunate was only available to patients through …

Continue reading FDA Approves Only Drug in U.S. to Treat Severe #Malaria

Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract

Abstract The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data, we demonstrate that ACE2 is expressed in a subset of secretory cells in the respiratory tract. Chronic …

Continue reading Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract

Predictors of a long length of stay in the emergency department for older people

..For older people, a long stay in the emergency department (ED) may reflect the complexity of their presentation, or deficiencies in systems that manage these complexities. ..Of 16 791 ED presentations made by older people, 4192 experienced a LLoS; 55% were admitted. Increasing age was associated with an increasing ED LoS. Factors most predictive of LLoS …

Continue reading Predictors of a long length of stay in the emergency department for older people

#Hydroxychloroquine or #chloroquine with or without a macrolide for treatment of #COVID-19: a multinational registry analysis

Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19.. ..96 032 patients (mean …

Continue reading #Hydroxychloroquine or #chloroquine with or without a macrolide for treatment of #COVID-19: a multinational registry analysis

Reducing #antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper

Highlights •Global & national AMR actions focus on infection prevention in healthcare settings. •Home & everyday life settings contribute to acquiring & spreading AMR pathogens. •Targeted hygiene protects against infections, reducing antibiotic prescribing. • Targeted hygiene helps to minimize selection pressure for AMR development globally. •Reducing AMR requires greater focus on targeted hygiene in the …

Continue reading Reducing #antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper