Primate auditory prototype in the evolution of the arcuate fasciculus

The human arcuate fasciculus pathway is crucial for #language, interconnecting posterior temporal and inferior frontal areas. Whether a monkey homolog exists is controversial and the nature of human-specific specialization unclear. Using monkey, ape and human auditory functional fields and diffusion-weighted MRI, we identified homologous pathways originating from the auditory cortex. This discovery establishes a primate auditory prototype for the arcuate fasciculus, reveals an earlier phylogenetic … Continue reading Primate auditory prototype in the evolution of the arcuate fasciculus

α-Synuclein-specific T cell reactivity is associated with preclinical and early #Parkinson’s disease

..diagnosis of motor Parkinson’s disease (PD) is preceded by a prolonged premotor phase with accumulating neuronal damage. Here we examined the temporal relation between α-synuclein (α-syn) T cell reactivity and PD. A longitudinal case study revealed that elevated α-syn-specific T cell responses were detected prior to the diagnosis of motor PD, and declined after. The relationship between T cell reactivity and early PD in two … Continue reading α-Synuclein-specific T cell reactivity is associated with preclinical and early #Parkinson’s disease