Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System

SARS-CoV2 host cell infection is mediated by the binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation observed in SARS-CoV was previously postulated to be due to ACE2/Ang1-7/Mas axis downregulation, increased ACE2 activity was shown to mediate disease protection. Since angiotensin II receptor blockers (ARBs), ACE inhibitors, and mineralocorticoid receptor antagonists (MRAs) increase ACE2 receptor expression, it has been tacitly believed that the use of these … Continue reading Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System

Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study

..A small thigh circumference is associated with an increased risk of diabetes, cardiovascular diseases, and total mortality. The purpose of this study was to evaluate the association between thigh circumference and hypertension in the middle-aged and elderly population. ..Thigh circumference was negatively correlated with systolic blood pressure, diastolic blood pressure, fasting glucose, and total cholesterol. Compared with the lowest thigh circumference tertile group, the risk … Continue reading Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study