IL-4 is a pleiotropic antiinflammatory cytokine, which can be neuroprotective after nervous system injury. The beneficial actions of IL-4 are thought to result from the blunting of action of inflammatory mediators, such as proinflammatory cytokines. Here, we demonstrate that IL-4 induces M2 macrophages to continuously produce opioid peptides and ameliorate pain. IL-4 application at injured … Continue reading #IL-4 induces M2 macrophages to produce sustained #analgesia via opioids
Day: Apr 4, 2020
.. During 2.3 years of follow-up, 19.1% (n = 97) of the men and 13.6% (n = 158) of the women developed incident hypertension. The adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for obesity (BMI ≥30) were 3.49 (1.59–7.66) and 2.60 (1.48–4.55) for men and women, respectively. A 1-point increase in BMI was associated … Continue reading Joint Effects of #Body Mass Index and Waist Circumference on the Incidence of #Hypertension in a Community-Based Chinese Population
