Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.

During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer’s disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The study population consisting of 69 untreated post-menopausal women were given … Continue reading Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.

Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation

Circadian (daily) regulation of metabolic pathways implies that food may be metabolized differentially over the daily cycle. To test that hypothesis, we monitored the metabolism of older subjects in a whole-room respiratory chamber over two separate 56-h sessions in a random crossover design. In one session, one of the 3 daily meals was presented as breakfast, whereas in the other session, a nutritionally equivalent meal … Continue reading Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation

MEANINGFUL CHANGE IN SIX-MINUTE #WALK IN PEOPLE WITH PERIPHERAL #ARTERY DISEASE

Six-minute walk is a common outcome in clinical trials of people with lower extremity peripheral artery disease (PAD). However, meaningful change in six-minute walk distance is not well defined in people with PAD.. ..777 participants with PAD (mean age: 71.2 years (standard deviation (SD)=8.8) mean baseline six-minute walk: 350.1 meters (SD=118.1) completed 5,439 questions about difficulty walking each WIQ distance at baseline and follow-up. Participants … Continue reading MEANINGFUL CHANGE IN SIX-MINUTE #WALK IN PEOPLE WITH PERIPHERAL #ARTERY DISEASE

Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2

The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function.. ..Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini‐Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status‐Modified (<30) and 0.48 for composite score (each … Continue reading Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2

A 2-year Double-Blind RCT Follow-up Study with Fermented #Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered #Neurodegenerative Disease-Risk Factors

In recent years a number of studies have reported the significant relationship between metabolic syndrome and neurodegenerative disease. There is accumulating evidence that the interplay of combined genetic and environmental risk factors (from diet to life style to pollutants) to intrinsic age-related oxi-inflammatory changes may be advocated for to explain the pandemic of neurodegenerative diseases. In recent years a specific Fermented Papaya Preparation (FPP) has … Continue reading A 2-year Double-Blind RCT Follow-up Study with Fermented #Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered #Neurodegenerative Disease-Risk Factors

#COVID-19: the critical balance between appropriate governmental restrictions and expected economic, psychological and social consequences in Italy. Are we going in the right direction?

Since the declaration of COVID-19 pandemic infection by the World Health Organization, many governmental restrictions have been differently applied in the involved countries in order to contain the spread of the infection; Italy applied severe restrictive, public measures actually confining the entire population to an almost complete lockdown for several weeks; the restrictive quarantine can be considered controversial when excessively prolonged over time, due to … Continue reading #COVID-19: the critical balance between appropriate governmental restrictions and expected economic, psychological and social consequences in Italy. Are we going in the right direction?

#Coronavirus: Lockdown’s heavy toll on Italy’s mental health

Italy’s coronavirus death toll is the second highest in the world, and its lockdown is the strictest and longest in Europe. Doctors say both things are creating a mental health emergency. The BBC has been given access to a psychological support centre run by the Red Cross, where staff say they’re overwhelmed by calls from people struggling. Psychologists are warning that Italy is not equipped … Continue reading #Coronavirus: Lockdown’s heavy toll on Italy’s mental health

Multicenter initial guidance on use of antivirals for children with #COVID-19/SARS-CoV-2

Although Coronavirus Disease 2019 (COVID-19) is mild in nearly all children, a small proportion of pediatric patients develops severe or critical illness. Guidance is therefore needed regarding use of agents with potential activity against severe acute respiratory syndrome coronavirus 2 in pediatrics.. ..Given the typically mild course of pediatric COVID-19, supportive care alone is suggested for the overwhelming majority of cases. The panel suggests a … Continue reading Multicenter initial guidance on use of antivirals for children with #COVID-19/SARS-CoV-2

#ST-Segment Elevation in Patients with #Covid-19 — A Case Series

Myocardial injury with ST-segment elevation has been observed in patients with coronavirus disease 2019 (Covid-19). Here, we describe our experience in the initial month of the Covid-19 outbreak in New York City. Patients with confirmed Covid-19 who had ST-segment elevation on electrocardiography were included in the study from six New York hospitals. Patients with Covid-19 who had nonobstructive disease on coronary angiography or had normal … Continue reading #ST-Segment Elevation in Patients with #Covid-19 — A Case Series

A salt-induced kinase is required for the metabolic regulation of #sleep

Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase (SIK) that signals sleep pressure, have low ATP levels despite … Continue reading A salt-induced kinase is required for the metabolic regulation of #sleep

Adherence to Life-Style Recommendations and #Attention-Deficit/Hyperactivity Disorder A Population-Based Study of Children Aged 10 to 11 Years

The incidence of attention-deficit/hyperactivity disorder (ADHD) among children and youth is high, and temporal increases have been paralleled by deteriorating life-styles. Poor diet quality, physical inactivity, poor sleep habits, and sedentary behaviors have all been associated with ADHD.. ..Before age 14 years, 10.8% of students received an ADHD diagnosis. Meeting recommendations for vegetables and fruit, meat and alternatives, saturated fat, added sugar, and physical activity … Continue reading Adherence to Life-Style Recommendations and #Attention-Deficit/Hyperactivity Disorder A Population-Based Study of Children Aged 10 to 11 Years

Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study

After diagnosis of a health condition, information about survival and potential transition from community into institutional care can be helpful for patients and care providers. We sought to describe the association between a new diagnosis of dementia and risk of admission to a long-term care home and death at 5 years.. ..age ≥ 90 yr; odds ratio [OR] 9.5, 95% confidence interval [CI] 8.8–10.2 [reference: … Continue reading Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study