Day: Mar 29, 2020

Gerontology, Neurology

BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study

Yongey Mingyur Rinpoche (YMR) is a Tibetan Buddhist monk, and renowned meditation practitioner and teacher who has spent an extraordinary number of hours of his life meditating. The brain-aging profile of this expert meditator in comparison to a control population was examined using a machine learning framework, which estimates “brain-age” from brain imaging. YMR’s brain-aging rate appeared slower than that of controls suggesting early maturation … Continue reading BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study

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Gastroenterology, Oncology

Intratumoral accumulation of gut #microbiota facilitates CD47-based immunotherapy via STING signaling

..Using one defined anaerobic gut microbiota to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilitates local anti-CD47 immunotherapy on tumor tissues through the capacity to accumulate within the tumor microenvironment. Systemic administration of Bifidobacterium leads to its accumulation within the tumor and converts the nonresponder mice into responders to anti-CD47 immunotherapy in a stimulator of interferon genes (STING)– and interferon-dependent fashion. … Continue reading Intratumoral accumulation of gut #microbiota facilitates CD47-based immunotherapy via STING signaling

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