#Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Our studies establish a connection between two isolated observations that 1) statins, taken by millions to lower cholesterol, have antitumor activity and 2) Ras-induced macropinocytosis is important in tumorigenesis. We discover that by depleting GGPP required for pseudopod extension and macropinocytosis, statins selectively kill cells with oncogenic defects by limiting nutrient uptake. https://bit.ly/2wT1ypw Continue reading #Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

#Colorectal Cancer Risk Following #Bariatric Surgery in a Nationwide Study of French Individuals With Obesity

..The mean (SD) follow-up was 6.2 (2.1) years for patients who underwent adjustable gastric banding, 5.5 (2.1) years for patients who underwent sleeve gastrectomy, and 5.7 (2.2) years for patients who underwent gastric bypass. In total, 13 052 incident colorectal cancers (1.2%) and 63 649 colorectal benign polyps were diagnosed. The rate of colorectal cancer was 0.6% in the bariatric surgery cohort and 1.3% in the cohort … Continue reading #Colorectal Cancer Risk Following #Bariatric Surgery in a Nationwide Study of French Individuals With Obesity