Factors Associated With #Mental Health Outcomes Among Health Care Workers Exposed to #Coronavirus Disease 2019

.. A total of 1257 of 1830 contacted individuals completed the survey, with a participation rate of 68.7%. A total of 813 (64.7%) were aged 26 to 40 years, and 964 (76.7%) were women. Of all participants, 764 (60.8%) were nurses, and 493 (39.2%) were physicians; 760 (60.5%) worked in hospitals in Wuhan, and 522 (41.5%) were frontline health care workers. A considerable proportion of … Continue reading Factors Associated With #Mental Health Outcomes Among Health Care Workers Exposed to #Coronavirus Disease 2019

The Effectiveness of Social #Distancing in Mitigating #COVID-19 Spread: a modelling analysis

..The application of all four social distancing interventions: school closure, workplace non-attendance, increased case isolation, and community contact reduction is highly effective in flattening the epidemic curve, reducing the maximum daily case numbers, and lengthening outbreak duration. These were also found to be effective even after 10 weeks delay from index case arrivals. The most effective single intervention was found to be increasing case isolation, … Continue reading The Effectiveness of Social #Distancing in Mitigating #COVID-19 Spread: a modelling analysis

Association of Daily #Step Count and Step Intensity With Mortality Among US Adults

..Accelerometer-measured number of steps per day and 3 step intensity measures (extended bout cadence, peak 30-minute cadence, and peak 1-minute cadence [steps/min]). Accelerometer data were based on measurements obtained during a 7-day period at baseline. .. A total of 4840 participants (mean age, 56.8 years; 2435 [54%] women; 1732 [36%] individuals with obesity) wore accelerometers for a mean of 5.7 days for a mean of … Continue reading Association of Daily #Step Count and Step Intensity With Mortality Among US Adults

Open Access Oral #glucocorticoids and incidence of #hypertension in people with chronic inflammatory diseases: a population-based cohort study

..Among 71 642 patients in the cohort, 24 896 (34.8%) developed hypertension during a median follow-up of 6.6 years. The incidence rate of hypertension was 46.7 (95% confidence interval [CI] 46.0–47.3) per 1000 person-years. Incidence rates increased with higher cumulative glucocorticoid prednisolone-equivalent dose, from 44.4 per 1000 person-years in periods of nonuse to 45.3 per 1000 person-years for periods with between > 0.0 and 959.9 … Continue reading Open Access Oral #glucocorticoids and incidence of #hypertension in people with chronic inflammatory diseases: a population-based cohort study

BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study

Yongey Mingyur Rinpoche (YMR) is a Tibetan Buddhist monk, and renowned meditation practitioner and teacher who has spent an extraordinary number of hours of his life meditating. The brain-aging profile of this expert meditator in comparison to a control population was examined using a machine learning framework, which estimates “brain-age” from brain imaging. YMR’s brain-aging rate appeared slower than that of controls suggesting early maturation … Continue reading BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study

Intratumoral accumulation of gut #microbiota facilitates CD47-based immunotherapy via STING signaling

..Using one defined anaerobic gut microbiota to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilitates local anti-CD47 immunotherapy on tumor tissues through the capacity to accumulate within the tumor microenvironment. Systemic administration of Bifidobacterium leads to its accumulation within the tumor and converts the nonresponder mice into responders to anti-CD47 immunotherapy in a stimulator of interferon genes (STING)– and interferon-dependent fashion. … Continue reading Intratumoral accumulation of gut #microbiota facilitates CD47-based immunotherapy via STING signaling

A Person Can Carry And Transmit #COVID-19 Without Showing Symptoms, Scientists Confirm

Chinese researchers have confirmed a case of asymptomatic transmission of the new coronavirus: A 20-year-old woman from Wuhan passed it to five of her family members but never got physically sick herself.. ..A report from the Chinese Centre for Disease Control and Prevention analysed records of all of China’s reported cases of the virus from December 8 to February 11 and found that 1.2 percent … Continue reading A Person Can Carry And Transmit #COVID-19 Without Showing Symptoms, Scientists Confirm

#Diet modulates brain network stability, a biomarker for brain #aging, in young adults

..One cohort was scanned under standard diet, overnight fasting, and ketogenic diet conditions. To isolate the impact of fuel type, an independent overnight fasted cohort was scanned before and after administration of a calorie-matched glucose and exogenous ketone ester (D-β-hydroxybutyrate) bolus. Across the life span, brain network destabilization correlated with decreased brain activity and cognitive acuity. Effects emerged at 47 y, with the most rapid … Continue reading #Diet modulates brain network stability, a biomarker for brain #aging, in young adults

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19

We report the kinetics of immune responses in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) that required hospitalization. Increased antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), activated CD4+ T cells and CD8+ T cells and immunoglobulin M (IgM) and IgG antibodies that bound the COVID-19-causing coronavirus SARS-CoV-2 were detected in blood before symptomatic recovery. These … Continue reading Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19

Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State

..A total of 21 cases were included (mean age, 70 years [range, 43-92 years]; 52% male). Comorbidities were identified in 18 cases (86%), with chronic kidney disease and congestive heart failure being the most common. Initial symptoms included shortness of breath (76%), fever (52%), and cough (48%) (Table 1). The mean onset of symptoms prior to presenting to the hospital was 3.5 days, and 17 … Continue reading Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State

Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity

..Visceral obesity is a key risk factor for type 2 diabetes (T2D). Whereas gut dysbiosis appears to be instrumental for this relationship, whether gut-associated signatures translocate to extra-intestinal tissues and how this affects host metabolism remain elusive ..We identified tissue-specific signatures with higher bacterial load in the liver and omental adipose tissue. Gut commensals, but also environmental bacteria, showed tissue- and T2D-specific compartmentalisation. T2D signatures … Continue reading Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity