The associations of major #foods and fibre with risks of ischaemic and haemorrhagic #stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

..For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82–0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69–0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91–0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85–0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81–0.97, P-trend = 0.008), while higher risk was observed with higher red meat consumption which attenuated … Continue reading The associations of major #foods and fibre with risks of ischaemic and haemorrhagic #stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

#Aspirin and #fracture risk: a systematic review and exploratory meta-analysis of observational studies

This review provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin. ..Aspirin use was associated with a 17% lower odds for any fracture (OR 0.83, 95% CI 0.70 to 0.99; I2=71%; six studies; n=511 390). Aspirin was associated with a higher total hip BMD for women (SMD 0.03, 95% CI −0.02 to … Continue reading #Aspirin and #fracture risk: a systematic review and exploratory meta-analysis of observational studies

Age at #period cessation and trajectories of #cardiovascular risk factors across mid and later life

To examine the association between age at period cessation and trajectories of anthropometry, blood pressure, lipids and glycated haemoglobin (HbA1c) from midlife to age 69 years.. ..We found no evidence that age at period cessation was associated with trajectories of log triglyceride, LDL-C and HDL-C from 53 to 69 years and trajectories of SBP or DBP from 36 to 69 years, regardless of whether period … Continue reading Age at #period cessation and trajectories of #cardiovascular risk factors across mid and later life

#Education, Race/Ethnicity, and Causes of Premature #Mortality Among Middle-Aged Adults in 4 US Urban Communities: Results From CARDIA, 1985–2017

..Our primary outcome was years of potential life lost (YPLL). Results. The age-adjusted mortality rate per 1000 persons was 45.17 among Black men, 25.20 among White men, 17.63 among Black women, and 10.10 among White women. Homicide and AIDS were associated with the most YPLL, but cancer and cardiovascular disease were the most common causes of death. In multivariable models, each level of education achieved … Continue reading #Education, Race/Ethnicity, and Causes of Premature #Mortality Among Middle-Aged Adults in 4 US Urban Communities: Results From CARDIA, 1985–2017

Association of Dual Decline in Memory and #Gait Speed With Risk for #Dementia Among Adults Older Than 60 Years

Dual decline in both memory and gait speed may characterize a group of older individuals at high risk for future dementia.. ..Participants were 60 years or older, had an initial gait speed of more than 0.6 m/s (ie, free of overt dismobility), with repeated measures of memory and gait speed before dementia diagnosis during a mean follow-up of 6.6 to 14.5 years. Within each study, … Continue reading Association of Dual Decline in Memory and #Gait Speed With Risk for #Dementia Among Adults Older Than 60 Years

The association between actor/partner #optimism and #cognitive functioning among older couples

Higher optimism has been linked with health, well‐being, and cognitive functioning. Spouses also play an important role on people’s health, especially in older adulthood.. ..Optimism was assessed at baseline (t1) and cognition was measured every two years with up to five repeated assessments of cognition data over the 8‐year follow‐up period (t1; t2; t3; t4; t5). Results Results from multi‐level dyadic data analyses showed small … Continue reading The association between actor/partner #optimism and #cognitive functioning among older couples

Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study

STUDY OBJECTIVES:Intensive care unit (ICU) nurses commonly work multiple consecutive 12-hr shifts that leave little time for sleep between work shifts. Working multiple consecutive shifts could compromise vigilance and patient care, especially with respect to managing high risk medications such as insulin infusions.. We identified patients who had hypoglycemia (glucose <=3.5mmol/l, 63 mg/dl) between December 2008 and December 2009 in 3 ICUs in Vancouver, British … Continue reading Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study

Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

..There was an increased risk of several cancers, including keratinocyte cancer (RR, 2.28; 95% CI, 1.73-3.01), lymphomas (RR, 1.56; 95% CI, 1.37-1.78), lung cancer (RR, 1.26; 95% CI, 1.13-1.40), and bladder cancer (RR, 1.12; 95% CI, 1.04-1.19). No increased risk of cancer for patients with psoriasis treated with biologic agents was found (RR, 0.97; 95% CI, 0.85-1.10). Psoriatic arthritis was not associated with increased risk … Continue reading Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

Gut #microbiota composition during infancy and subsequent #behavioural outcomes

..The faecal microbiota were analysed at 1, 6, and 12 months of age. Behavioural outcomes were measured at 2 years of age. Findings In an unselected birth cohort, we found a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years, in particular Internalizing Problem scores. This association appeared independent of … Continue reading Gut #microbiota composition during infancy and subsequent #behavioural outcomes

Lung #MRI as a Potential Complementary Diagnostic Tool for Early #COPD

Many knowledge gaps in the nature of early chronic obstructive pulmonary disease (COPD) still exist, mainly because COPD has always been considered a disease of the elderly. Little attention has been paid to the pathologic changes in the lungs of young adults with risk factors for COPD, such as bronchopulmonary dysplasia. One major limitation is the current lack of noninvasive ways to sensitively measure or … Continue reading Lung #MRI as a Potential Complementary Diagnostic Tool for Early #COPD

Body #mass index, #diabetes, and the risk of #Parkinson’s disease

..A total of 33,443 individuals were diagnosed with PD during the follow‐up period (7.3 years). An increased risk of PD incidence was observed in the underweight group versus the normal group (adjusted hazard ratio: 1.28; 95% confidence interval: 1.21–1.36), whereas a decreased risk of PD incidence was observed (adjusted hazard ratio: 0.88; 95% confidence interval: 0.88–0.93) in the obese group and (adjusted hazard ratio: 0.77; 95% … Continue reading Body #mass index, #diabetes, and the risk of #Parkinson’s disease