Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study

… According to the criteria, 57% (52% to 62%) of the 130.5 million prescriptions were for appropriate indications, 25% (21% to 29%) were inappropriate, and 18% (15% to 22%) had no documented indication. This corresponds to an estimated 24 million prescriptions without a documented indication. Being an adult male, spending more time with the provider, and seeing a non-primary care specialist were significantly positively associated … Continue reading Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study

Use of #anastrozole for #breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial

..3864 women were recruited between Feb 2, 2003, and Jan 31, 2012. 1920 women were randomly assigned to 5 years anastrozole and 1944 to placebo. After a median follow-up of 131 months (IQR 105–156), a 49% reduction in breast cancer was observed for anastrozole (85 vs 165 cases, hazard ratio [HR] 0·51, 95% CI 0·39–0·66, p<0·0001). The reduction was larger in the first 5 years … Continue reading Use of #anastrozole for #breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial