Application of non-HDL #cholesterol for population-based #cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

..Incidence curve analyses showed progressively higher 30-year cardiovascular disease event-rates for increasing non-HDL cholesterol categories (from 7·7% for non-HDL cholesterol <2·6 mmol/L to 33·7% for ≥5·7 mmol/L in women and from 12·8% to 43·6% in men; p<0·0001). Multivariable adjusted Cox models with non-HDL cholesterol lower than 2·6 mmol/L as reference showed an increase in the association between non-HDL cholesterol concentration and cardiovascular disease for both … Continue reading Application of non-HDL #cholesterol for population-based #cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

Rising rural body-mass index is the main driver of the global #obesity epidemic in adults

Body-mass index (#BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity.. ..We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI … Continue reading Rising rural body-mass index is the main driver of the global #obesity epidemic in adults

Association of #Step Volume and Intensity With All-Cause #Mortality in Older Women

A goal of 10 000 steps/d is commonly believed by the public to be necessary for health, but this number has limited scientific basis.. ..In spline analysis, HRs were observed to decline progressively with higher mean steps per day until approximately 7500 steps/d, after which they leveled. For measures of stepping intensity, higher intensities were associated with significantly lower mortality rates; however, after adjusting for steps … Continue reading Association of #Step Volume and Intensity With All-Cause #Mortality in Older Women

#Injuries associated with electric-powered bikes and scooters: analysis of US consumer product data

..While persons injured using #E-bikes were more likely to suffer internal injuries (17.1%; 95% CI 5.6 to 28.6) and require hospital admission (OR=2.8, 95% CI 1.3 to 6.1), powered scooter injuries were nearly three times more likely to result in a diagnosis of concussion (3% of scooter injuries vs 0.5% of E-bike injuries). E-bike-related injuries were also more than three times more likely to involve a collision … Continue reading #Injuries associated with electric-powered bikes and scooters: analysis of US consumer product data

#Exercise capacity and #body mass index – important predictors of change in resting #heart rate

Resting heart rate (RHR) is an obtainable, inexpensive, non-invasive test, readily available on any medical document. RHR has been established as a risk factor for cardiovascular morbidity, is related to other cardiovascular risk factors, and may possibly predict them. Change in RHR over time (∆RHR) has been found to be a potential predictor of mortality.. In this prospective study, RHR and ∆RHR were evaluated at … Continue reading #Exercise capacity and #body mass index – important predictors of change in resting #heart rate

Drinking Water #Salinity, Urinary Macro‐Mineral Excretions, and Blood #Pressure in the Southwest Coastal Population of Bangladesh

Sodium (Na+) in saline water may increase blood pressure (BP), but potassium (K+), calcium (Ca2+), and magnesium (Mg2+) may lower BP. We assessed the association between drinking water salinity and population BP.. ..fresh water (electrical conductivity, <0.7 mS/cm), mild salinity (electrical conductivity ≥0.7 and <2 mS/cm), and moderate salinity (electrical conductivity ≥2 and <10 mS/cm).. ..Compared with fresh water drinkers, mild‐salinity water drinkers had lower … Continue reading Drinking Water #Salinity, Urinary Macro‐Mineral Excretions, and Blood #Pressure in the Southwest Coastal Population of Bangladesh

Efficacy and Safety of Low-Dose #Colchicine after Myocardial #Infarction

We performed a randomized, double-blind trial involving patients recruited within 30 days after a myocardial infarction. The patients were randomly assigned to receive either low-dose colchicine (0.5 mg once daily) or placebo.. ..The primary end point occurred in 5.5% of the patients in the colchicine group, as compared with 7.1% of those in the placebo group (hazard ratio, 0.77; 95% confidence interval [CI], 0.61 to … Continue reading Efficacy and Safety of Low-Dose #Colchicine after Myocardial #Infarction

A Review of the In Vivo Evidence Investigating the Role of #Nitrite Exposure from Processed Meat Consumption in the Development of Colorectal #cancer

..The World Cancer Research Fund (WCRF) 2007 stated that the consumption of processed meat is a convincing cause of colorectal cancer (CRC), and therefore, the public should avoid it entirely. Sodium nitrite has emerged as a putative candidate responsible for the CRC-inducing effects of processed meats. Sodium nitrite is purported to prevent the growth of Clostridium botulinum and other food-spoiling bacteria, but recent, contradictory peer-reviewed … Continue reading A Review of the In Vivo Evidence Investigating the Role of #Nitrite Exposure from Processed Meat Consumption in the Development of Colorectal #cancer

Does type 2 #diabetes confer higher relative rates of #cardiovascular events in women compared with men?

..calculate overall and age-dependent incidence rates, incidence rate ratios, and women-to-men ratios for myocardial infarction, heart failure, ischaemic stroke, or cardiovascular death (MACE-HF). Among 218 549 (46% women) individuals with diabetes, the absolute rate of MACE-HF was higher in men than in women (24.9 vs. 19.9 per 1000 person-years). Corresponding absolute rates in men and women without diabetes were 10.1 vs. 7.0 per 1000 person-years. … Continue reading Does type 2 #diabetes confer higher relative rates of #cardiovascular events in women compared with men?

Clustering of #lifestyle risk factors for non-communicable diseases in 304,779 #adolescents from 89 countries: A global perspective

The precursors of non-communicable diseases (NCDs) are often manifested during childhood and adolescence with little knowledge about co-occurrence of their related lifestyle risk factors. .. ..Adolescents aged 16–17 years, compared to those aged 11–13 years, had higher odds (OR 1.33; 95% CI 1.31–1.36) of reporting ≥3 risk factors. Risk factors clustered in multiple combinations and differed by sex. The clustering of physical inactivity and low … Continue reading Clustering of #lifestyle risk factors for non-communicable diseases in 304,779 #adolescents from 89 countries: A global perspective

Occupational #radiation exposure and excess additive risk of #cataract incidence in a cohort of US radiologic technologists

..There were 11 345 cataract diagnoses and 5440 of cataract surgery during 832 462 and 888 402 person-years of follow-up, respectively. Cumulative occupational radiation exposure was associated with self-reported cataract, but not with cataract surgery, with EAR/104 person-year Gy=94 (95% CI: 47 to 143, p<0.001) and EAR/104 person-year Gy=13 (95% CI: <0 to 57, p=0.551), respectively. There was marked (p<0.001) variation of EAR by age and by diabetes … Continue reading Occupational #radiation exposure and excess additive risk of #cataract incidence in a cohort of US radiologic technologists