Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke

The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown. ..Throughout the overall follow-up period, the mean BP was 133.2/77.7 (95% CI, 132.5-133.8/77.1-78.4) mm Hg … Continue reading Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke

Phase 2a randomized, placebo-controlled study of anti–IL-33 in peanut #allergy

IL-33, found in high levels in participants with allergic disorders, is thought to mediate allergic reactions. Etokimab, an anti–IL-33 biologic, has previously demonstrated a good safety profile and favorable pharmacodynamic properties in many clinical studies ..Efficacy measurements for active vs. placebo participants at the day 15 and 45 food challenge (tolerating a cumulative 275 mg of #peanut protein, which was the food challenge outcome defined … Continue reading Phase 2a randomized, placebo-controlled study of anti–IL-33 in peanut #allergy