Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity

..1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role of vitamin D-VDR signalling and replicated the findings in TCGA … Continue reading Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity

#Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies

..We assessed the association of incident dementia and clinical Alzheimer’s disease with use of five AHM classes, within strata of baseline high (systolic blood pressure [SBP] ≥140 mm Hg or diastolic blood pressure [DBP] ≥90 mm Hg) and normal (SBP <140 mm Hg and DBP <90 mm Hg) blood pressure. ..There were 3728 incident cases of dementia and 1741 incident Alzheimer’s disease diagnoses. In the … Continue reading #Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies