Potato ingestion is as effective as carbohydrate gels to support prolonged #cycling performance

We investigated the effects of potato purée ingestion during prolonged cycling on subsequent performance versus commercial CHO gel or a water-only condition. Twelve cyclists (70.7 ± 7.7 kg, 173 ± 8 cm, 31± 9 years, 22 ± 5.1 % body fat; mean ± SD) with average peak oxygen consumption (VO2PEAK)of 60.7 ± 9.0 mL/kg/min performed a 2 h cycling challenge (60-85%VO2PEAK) followed by a time … Continue reading Potato ingestion is as effective as carbohydrate gels to support prolonged #cycling performance

Association Between High School #Personality Phenotype and #Dementia 54 Years Later in Results From a National US Sample

To examine whether personality during adolescence—a time when preclinical dementia pathology is unlikely to be present—confers risk of dementia in later life and to test whether associations could be accounted for by health factors in adolescence or differed across socioeconomic status (SES). Lower risk of dementia was associated with higher levels of vigor (hazard ratio for 1 SD, 0.93; 95% CI, 0.90-0.97; P < .001). Calm and … Continue reading Association Between High School #Personality Phenotype and #Dementia 54 Years Later in Results From a National US Sample

Regulation of #lifespan by #neural excitation and REST

..Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function. In Caenorhabditis elegans, neural excitation increases with age and inhibition of excitation globally, or in glutamatergic or cholinergic neurons, increases longevity. Furthermore, longevity is dynamically regulated by the excitatory–inhibitory balance of neural … Continue reading Regulation of #lifespan by #neural excitation and REST