Randomized Trial of Medical versus Surgical Treatment for Refractory #Heartburn

..Heartburn that persists despite proton-pump inhibitor ( #PPI ) treatment is a frequent clinical problem with multiple potential causes. Treatments for PPI-refractory heartburn are of unproven efficacy and focus on controlling gastroesophageal reflux with reflux-reducing medication (e.g., baclofen) or antireflux surgery or on dampening visceral hypersensitivity with neuromodulators (e.g., desipramine). Prerandomization procedures excluded 288 patients: 42 had relief of their heartburn during the 2-week omeprazole … Continue reading Randomized Trial of Medical versus Surgical Treatment for Refractory #Heartburn

Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study

..Compared with participants who remained at normal weight, those moving from the non-obese to obese category between young and middle adulthood had a 22% (hazard ratio 1.22, 95% confidence interval 1.11 to 1.33) and 49% (1.49, 1.21 to 1.83) higher risk of all cause mortality and heart disease mortality, respectively. Changing from obese to non-obese body mass index over this period was not significantly associated … Continue reading Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study