IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with rising incidence. Diseased tissues are heavily vascularized ..Specifically, we show that inhibition of the IFN-γ response in vessels by endothelial-specific knockout of IFN-γ receptor 2 ameliorates experimentally induced colitis in mice. IFN-γ acts pathogenic by causing a breakdown of the vascular barrier through disruption of the adherens junction protein VE-cadherin. Notably, intestinal vascular barrier dysfunction … Continue reading IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption

Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial

..exploring the effects of chair yoga (CY), compared to music intervention (MI) and chair-based exercise (CBE) in this population. Using a cluster randomized controlled trial (RCT), 3 community sites were randomly assigned 1:1:1 to CY, MI, or CBE. Participants attended twice-weekly 45-minute sessions for 12 weeks.. The CY group improved significantly in quality of life compared to the MI group .. However, no significant group … Continue reading Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial

Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model

Results Anticoagulation with dabigatran prevented memory decline, cerebral hypoperfusion, and toxic fibrin deposition in the AD mouse brain. In addition, long-term dabigatran treatment significantly reduced the extent of amyloid plaques, oligomers, phagocytic microglia, and infiltrated T cells by 23.7%, 51.8%, 31.3%, and 32.2%, respectively. Dabigatran anticoagulation also prevented AD-related astrogliosis and pericyte alterations, and maintained expression of the water channel aquaporin-4 at astrocytic perivascular endfeet … Continue reading Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model