Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

Highlights • Addition of fructose to a high-fat diet increases hepatic malonyl-CoA more than glucose •Knockdown of the fructose metabolizing gene ketohexokinase increases CTP1a levels •Fructose supplementation alters mitochondrial size and function •Dietary fructose induces acetylation of ACADL and CPT1a to modify fat oxidation In summary, dietary fructose, but not glucose, supplementation of HFD impairs mitochondrial size, function, and protein acetylation, resulting in decreased fatty … Continue reading Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR

People receiving their first opioid prescription were propensity matched to people receiving NSAIDS (and, in sensitivity analysis, gabapentinoids) and the risk of death and hospitalization were compared, classifying opioid medication exposure as time-varying daily oral morphine milligram equivalents (MMEs) across time-varying eGFR. Prescriptions for 1–59 and ≥60 MMEs were associated with higher risk of death .. and hospitalization.. compared with NSAID prescriptions, when evaluated at … Continue reading Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR